The accident happened shortly after 4 a.m. at the intersection of Irving Park and Western Avenue, according to the Chicago Fire Department.
A Lexus T-boned an Audi in the middle of the intersection, sending the driver of the Lexus through the windshield. Two others involved in the accident had to be extricated from their vehicles by rescue personnel.
Emergency personnel reported that there were four men and one woman, ages 25 to 33, in the Audi and two men in the Lexus, ages 30 and 32, according to the Breaking News Center.
The roads were wet from recent rain at the time of the accident, which remains under investigation.
As we reported last month on Chicago Car Accident Lawyers blog, intersections are among the most dangerous places for car accidents; about 250 fatal crashes occur at intersections each year in Illinois and crashes at intersections account for about 1 in 5 fatal accidents nationwide.