The accident involved two semis and a car and occurred about 10:30 p.m. Monday in the southbound local lanes near 63rd Street. The lanes were closed to traffic until early Tuesday morning as work crews cleared the scene, the Sun-Times reported.
A semi rear-ended a car as it slowed while approaching slower traffic, according to Illinois State Police. The semi was then struck by another semi, which caught fire.
The driver of the second semi was cited for following too closely.
A woman and three men were injured in the crash. One victim was taken in serious to critical condition to Christ Medical Center in Oak Lawn; one was taken in serious to critical condition to the University of Chicago Hospitals.
The other two were taken in good to fair condition, to the University of Chicago Hospitals and St. Bernard Hospital.
In 2008, there were 14,632 Illinois trucking accidents, which claimed 115 lives and injured 2,940, according to the Illinois Department of Transportation.
Chicago trucking accidents account for the vast majority of Illinois semi accidents. More than 12,000 of the accidents occurred in urban areas.